Gender-related prognostic significance of clinical and biological tumor features in rectal cancer patients receiving short-course preoperative radiotherapy

COX-2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy

To determine the impact of cyclooxygenase-2 (COX-2) expression on clinical behavior in irradiated and non-irradiated rectal carcinomas. Tumor samples were collected from 1231 patients of the Dutch TME trial in which rectal cancer patients were treated with standardized surgery, and randomized for pre-operative short-term (5 times 5Gy) radiotherapy or no pre-operative radiotherapy. Tissue micro ...

Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy.

PURPOSE To determine the effect of cyclooxygenase (COX)-2 expression on clinical behavior in irradiated and nonirradiated rectal carcinomas. EXPERIMENTAL DESIGN Tumor samples were collected from 1,231 patients of the Dutch TME trial, in which rectal cancer patients were treated with standardized surgery and randomized for preoperative short-term (5 x 5 Gy) radiotherapy or no preoperative radi...

Preoperative short-course radiotherapy in rectal cancer patients: results and prognostic factors

Objective The purpose of this study was to evaluate the clinical outcome of preoperative short-course radiotherapy for rectal cancer patients. Methods The study group comprised 210 patients with pathologically proven resectable rectal cancer. Between 2001 and 2013, they were treated preoperatively with short-course radiotherapy (25 Gy delivered in five fractions), followed by total mesorectal...

Preoperative radiotherapy "short course" in rectal cancer in elder patient: low impact on tumor regression

Clinical results and toxicity for short-course preoperative radiotherapy and total mesorectal excision in rectal cancer patients

Short-course preoperative radiotherapy (SCPRT) is an alternative method to chemoirradiation for patients with Stage II and III rectal cancer when no downsizing is needed, but there is still widespread reluctance to use this method because of fear of side effects from high-fraction doses. This paper reports on a single institution patient cohort of operated rectal cancer patients after SCPRT, ev...